Capping off the ends
نویسندگان
چکیده
منابع مشابه
Protection of Drosophila chromosome ends through minimal telomere capping.
In Drosophila, telomere-capping proteins have the remarkable capacity to recognize chromosome ends in a sequence-independent manner. This epigenetic protection is essential to prevent catastrophic ligations of chromosome extremities. Interestingly, capping proteins occupy a large telomere chromatin domain of several kilobases; however, the functional relevance of this to end protection is unkno...
متن کاملQuick hops on and off plus ends
A newly identifi ed traffi cking pathway takes a cell surface protein to the inner nuclear membrane (INM), reveal Hieda et al. In its nuclear envelope locale, the protein can reactivate cell cycle genes. Activation of the cell cycle is an important job for EGF family members. These trans-membrane proteins start out on the plasma membrane but are cleaved when cells receive mitogenic cues, thereb...
متن کاملCoordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein
Exposure of cryptic actin filament fast growing ends (barbed ends) initiates actin polymerization in stimulated human and mouse platelets. Gelsolin amplifies platelet actin assembly by severing F-actin and increasing the number of barbed ends. Actin filaments in stimulated platelets from transgenic gelsolin-null mice elongate their actin without severing. F-actin barbed end capping activity per...
متن کاملDynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides
Bursts of actin polymerization in vivo involve the transient appearance of free barbed ends. To determine how rapidly barbed ends might appear and how long they might remain free in vivo, we studied the kinetics of capping protein, the major barbed end capper, binding to barbed ends in vitro. First, the off-rate constant for capping protein leaving a barbed end is slow, predicting a half-life f...
متن کاملCdc13 telomere capping decreases Mec1 association but does not affect Tel1 association with DNA ends.
Chromosome ends, known as telomeres, have to be distinguished from DNA breaks that activate DNA damage checkpoint. Two large protein kinases, ataxia-teleangiectasia mutated (ATM) and ATM-Rad3-related (ATR), control not only checkpoint activation but also telomere length. In budding yeast, Mec1 and Tel1 correspond to ATR and ATM, respectively. Here, we show that Cdc13-dependent telomere capping ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 1999
ISSN: 0028-0836,1476-4687
DOI: 10.1038/16598